Zhang Geoff G Z, Henry Rodger F, Borchardt Thomas B, Lou Xiaochun
J Pharm Sci. 2007 May;96(5):990-5. doi: 10.1002/jps.20949.
We have extended the established physical stability treatment for hydrates/solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency.
我们已将既定的水合物/溶剂化物物理稳定性处理方法扩展至与固体共晶形成物形成的共晶体。基于所提出的处理方法，开发了一种悬浮液/浆液筛选技术，并在16个药物共晶体系中进行了测试，取得了成功。该理论处理方法和实际筛选技术应会有助于共结晶领域的研究人员提高筛选效率。
