Aktories Klaus
Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University of Freiburg, D-79104 Freiburg, Germany.
ACS Chem Biol. 2007 Apr 24;2(4):228-30. doi: 10.1021/cb7000654.
Clostridium difficile toxins A and B are the major cause of antibiotic-associated diarrhea and pseudomembranous colitis. The toxins are one of the biggest protein toxins known, but only the N-terminal catalytic domains of the large proteins enter the cytosol. Now, a new study shows that the toxins are processed by autocatalytic cleavage, which depends on the presence of inositol hexaphosphate.
艰难梭菌毒素A和B是抗生素相关性腹泻和伪膜性结肠炎的主要病因。这些毒素是已知最大的蛋白质毒素之一，但只有这些大蛋白的N端催化结构域进入细胞质溶胶。现在，一项新研究表明，这些毒素通过自催化切割进行加工，这取决于肌醇六磷酸的存在。
