梭菌属糖基化毒素的结构与作用模式：ABCD模型
Structure and mode of action of clostridial glucosylating toxins: the ABCD model.
作者信息
Jank Thomas, Aktories Klaus
机构信息
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg, Otto-Krayer-Haus, Albertstrasse 25, D-79104 Freiburg, Germany.
出版信息
Trends Microbiol. 2008 May;16(5):222-9. doi: 10.1016/j.tim.2008.01.011. Epub 2008 Apr 18.
Toxins A and B, which are the major virulence factors of antibiotic-associated diarrhea and pseudomembranous colitis caused by Clostridium difficile, are the prototypes of the family of clostridial glucosylating toxins. The toxins inactivate Rho and Ras proteins by glucosylation. Recent findings on the autocatalytic processing of the toxins and analysis of the crystal structures of their domains have made a revision of the current model of their actions on the eukaryotic target cells necessary.
毒素A和毒素B是艰难梭菌引起的抗生素相关性腹泻和假膜性结肠炎的主要毒力因子，是梭菌属糖基化毒素家族的原型。这些毒素通过糖基化使Rho和Ras蛋白失活。最近关于毒素自催化加工的研究结果及其结构域晶体结构的分析，使得有必要对目前它们作用于真核靶细胞的模型进行修正。
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