Palladin mutation causes familial pancreatic cancer: absence in European families.
作者信息
Slater Emily, Amrillaeva Vera, Fendrich Volker, Bartsch Detlef, Earl Julie, Vitone Louis J, Neoptolemos John P, Greenhalf William
出版信息
PLoS Med. 2007 Apr;4(4):e164. doi: 10.1371/journal.pmed.0040164.
Abstract
摘要
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Palladin mutation causes familial pancreatic cancer: absence in European families.帕拉丁基因突变导致家族性胰腺癌：在欧洲家族中不存在。
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Absence of deleterious palladin mutations in patients with familial pancreatic cancer.家族性胰腺癌患者中无有害的帕拉丁基因突变。
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PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.一个欧洲家族的 PALLD 突变导致家族性胰腺癌的基质倾向性。
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[Familial pancreatic cancer and the palladin gene: a new look at cancer mechanisms].
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The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.P239S 原肌球蛋白变异体在遗传性或早发性胰腺癌中所占比例并不显著。
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Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion.激活肿瘤相关基质：palladin 的过表达激活成纤维细胞促进肿瘤侵袭。
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本文引用的文献
1
Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.帕拉丁基因突变导致家族性胰腺癌，并提示一种新的癌症机制。
PLoS Med. 2006 Dec;3(12):e516. doi: 10.1371/journal.pmed.0030516.
2
Evaluation of the 4q32-34 locus in European familial pancreatic cancer.欧洲家族性胰腺癌中4q32 - 34位点的评估
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1948-55. doi: 10.1158/1055-9965.EPI-06-0376.
3
A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.一个新的常染色体显性遗传性胰腺癌易感基因座定位于4号染色体的q32 - 34区域。
Am J Hum Genet. 2002 Apr;70(4):1044-8. doi: 10.1086/339692. Epub 2002 Feb 27.
4
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome.八个携带CDKN2A种系突变的扩展性家族性非典型多发性痣黑色素瘤-胰腺癌易感家族的表型变异：家族性非典型痣黑色素瘤-胰腺癌综合征
Cancer. 2002 Jan 1;94(1):84-96. doi: 10.1002/cncr.10159.
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