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Palladin mutation causes familial pancreatic cancer: absence in European families.

作者信息

Slater Emily, Amrillaeva Vera, Fendrich Volker, Bartsch Detlef, Earl Julie, Vitone Louis J, Neoptolemos John P, Greenhalf William

出版信息

PLoS Med. 2007 Apr;4(4):e164. doi: 10.1371/journal.pmed.0040164.

DOI:10.1371/journal.pmed.0040164
PMID:17455999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1855695/
Abstract
摘要

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1
Palladin mutation causes familial pancreatic cancer: absence in European families.帕拉丁基因突变导致家族性胰腺癌：在欧洲家族中不存在。
PLoS Med. 2007 Apr;4(4):e164. doi: 10.1371/journal.pmed.0040164.
2
Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.帕拉丁基因突变导致家族性胰腺癌，并提示一种新的癌症机制。
PLoS Med. 2006 Dec;3(12):e516. doi: 10.1371/journal.pmed.0030516.
3
Absence of deleterious palladin mutations in patients with familial pancreatic cancer.家族性胰腺癌患者中无有害的帕拉丁基因突变。
Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1328-30. doi: 10.1158/1055-9965.EPI-09-0056. Epub 2009 Mar 31.
4
PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.一个欧洲家族的 PALLD 突变导致家族性胰腺癌的基质倾向性。
JCI Insight. 2021 Mar 25;6(8):141532. doi: 10.1172/jci.insight.141532.
5
[Familial pancreatic cancer and the palladin gene: a new look at cancer mechanisms].
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6
Familial pancreatic-cancer gene found.
Lancet Oncol. 2007 Jan;8(1):14. doi: 10.1016/s1470-2045(06)70998-6.
7
The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.P239S 原肌球蛋白变异体在遗传性或早发性胰腺癌中所占比例并不显著。
Hum Genet. 2007 Jun;121(5):635-7. doi: 10.1007/s00439-007-0361-z. Epub 2007 Apr 6.
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Familial pancreatic cancer: hope can become truth.
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Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion.激活肿瘤相关基质：palladin 的过表达激活成纤维细胞促进肿瘤侵袭。
PLoS One. 2012;7(1):e30219. doi: 10.1371/journal.pone.0030219. Epub 2012 Jan 23.
10
Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells.Palladin在胰腺浸润性导管腺癌的非肿瘤性基质中过表达，但在肿瘤细胞中仅偶尔过表达。
Cancer Biol Ther. 2007 Mar;6(3):324-8. doi: 10.4161/cbt.6.3.3904. Epub 2007 Mar 24.

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From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression.从癌前病变到癌症：解析胰腺上皮内瘤变进展的内在和外在途径。
Carcinogenesis. 2024 Nov 22;45(11):801-816. doi: 10.1093/carcin/bgae064.
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Exploring the potential role of palladin in modulating human CAF/ECM functional units.探索帕拉丁在调节人癌相关成纤维细胞/细胞外基质功能单元中的潜在作用。
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Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities.成年心脏中 paladin 的消融导致扩张型心肌病，伴有闰盘异常。
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PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.一个欧洲家族的 PALLD 突变导致家族性胰腺癌的基质倾向性。
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The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years.德国国家家族性胰腺癌病例集（FaPaCa）——20年所获知识
Dtsch Arztebl Int. 2021 Mar 12;118(10):163-8. doi: 10.3238/arztebl.m2021.0004.
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Genomic Features and Clinical Management of Patients with Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.遗传性胰腺癌综合征和家族性胰腺癌患者的基因组特征和临床管理。
Int J Mol Sci. 2019 Jan 29;20(3):561. doi: 10.3390/ijms20030561.
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Oncotarget. 2017 Apr 20;8(42):73240-73257. doi: 10.18632/oncotarget.17291. eCollection 2017 Sep 22.
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Familial Pancreatic Cancer and the Future of Directed Screening.家族性胰腺癌与定向筛查的未来。
Gut Liver. 2017 Nov 15;11(6):761-770. doi: 10.5009/gnl16414.
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ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.ACG 临床指南：遗传性胃肠道癌综合征的基因检测与管理。
Am J Gastroenterol. 2015 Feb;110(2):223-62; quiz 263. doi: 10.1038/ajg.2014.435. Epub 2015 Feb 3.

本文引用的文献

1
Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.帕拉丁基因突变导致家族性胰腺癌，并提示一种新的癌症机制。
PLoS Med. 2006 Dec;3(12):e516. doi: 10.1371/journal.pmed.0030516.
2
Evaluation of the 4q32-34 locus in European familial pancreatic cancer.欧洲家族性胰腺癌中4q32 - 34位点的评估
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1948-55. doi: 10.1158/1055-9965.EPI-06-0376.
3
A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.一个新的常染色体显性遗传性胰腺癌易感基因座定位于4号染色体的q32 - 34区域。
Am J Hum Genet. 2002 Apr;70(4):1044-8. doi: 10.1086/339692. Epub 2002 Feb 27.
4
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome.八个携带CDKN2A种系突变的扩展性家族性非典型多发性痣黑色素瘤-胰腺癌易感家族的表型变异：家族性非典型痣黑色素瘤-胰腺癌综合征
Cancer. 2002 Jan 1;94(1):84-96. doi: 10.1002/cncr.10159.