家族性胰腺癌患者中无有害的帕拉丁基因突变。
Absence of deleterious palladin mutations in patients with familial pancreatic cancer.
作者信息
Klein Alison P, Borges Michael, Griffith Margaret, Brune Kieran, Hong Seung-Mo, Omura Noriyuki, Hruban Ralph H, Goggins Michael
机构信息
Department of Pathology, The John Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1328-30. doi: 10.1158/1055-9965.EPI-09-0056. Epub 2009 Mar 31.
Abstract
It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.
摘要
据报道，帕拉丁基因（PALLD）的种系突变会导致胰腺癌的家族聚集，但证据薄弱且存在争议。我们对48名家族性胰腺癌患者的PALLD编码区进行了测序。我们没有发现任何有害突变，也没有证据表明PALLD突变是家族性胰腺癌的病因。
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