Speights V O, Bauserman S C
Department of Surgical Pathology, Scott & White Clinic and Memorial Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University College of Medicine, Temple 76508.
Pediatr Pathol. 1991 Sep-Oct;11(5):751-8. doi: 10.3109/15513819109065470.
Some deaths during the first year of life are classified as sudden infant death syndrome (SIDS), the diagnosis of which requires a complete autopsy without adequate explanation for the death. We report a 1-month-old infant whose clinical history was fairly typical for SIDS. Postmortem examination was remarkable in revealing clinically unsuspected central nervous system (CNS) abnormalities, including lobar holoprosencephaly, absence of the olfactory tracts and grooves (arhinencephaly), subependymal gray matter heterotopias, and delayed myelination. Although the CNS findings do not adequately explain the patient's sudden death, this case illustrates the need for a complete autopsy to include careful CNS evaluation, especially in any presumed SIDS death.
一岁以内婴儿的某些死亡被归类为婴儿猝死综合征（SIDS），该病症的诊断需要进行完整尸检且死因无法得到充分解释。我们报告了一名1个月大的婴儿，其临床病史相当符合SIDS的典型特征。尸检结果显示出临床上未被怀疑的中枢神经系统（CNS）异常，包括叶型全前脑畸形、嗅束和嗅沟缺失（无嗅脑畸形）、室管膜下灰质异位以及髓鞘形成延迟，令人瞩目。尽管中枢神经系统的检查结果无法充分解释患者的猝死，但该病例表明，即使是对于任何疑似SIDS的死亡病例，都需要进行完整尸检，包括对中枢神经系统进行仔细评估。
