Murray T K, Cross A J, Green A R
Astra Neuroscience Research Unit, London, UK.
Psychopharmacology (Berl). 1991;105(1):134-6. doi: 10.1007/BF02316877.
The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.
使用操作性延迟位置不匹配任务，研究了胆碱酯酶抑制剂毒扁豆碱和他克林（THA）对东莨菪碱诱导的记忆和行为缺陷的影响。单独给予毒扁豆碱（0.1mg/kg腹腔注射）或他克林（1mg/kg腹腔注射）时，未观察到对大鼠行为表现的影响。然而，相同剂量的胆碱酯酶抑制剂可逆转东莨菪碱（0.03mg/kg皮下注射）在该任务中诱导的行为缺陷。
