Rupniak N M, Field M J, Samson N A, Steventon M J, Iversen S D
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
Neurobiol Aging. 1990 Nov-Dec;11(6):609-13. doi: 10.1016/0197-4580(90)90025-u.
Cognitive facilitation by physostigmine and tetrahydroaminoacridine (THA) was compared in two primate models. Disruption of spatial delayed response performance by scopolamine (0.03 mg/kg) was fully reversed by coadministration of 5 doses of physostigmine in the range 0.03-0.08 mg/kg, but by only one dose (4.0 mg/kg) of THA; partial reversal of some effects of scopolamine was observed at 1 and 3 mg/kg of THA. Visual recognition memory was enhanced following treatment with 4 doses of physostigmine in the range 0.001-0.03 mg/kg. The effect of THA across the group of animals was not significant but performance tended to improve using a dose of 0.8 mg/kg. Our findings indicate that THA does not have a superior profile to physostigmine as a cognitive enhancer in primates.
在两种灵长类动物模型中比较了毒扁豆碱和他克林（THA）对认知的促进作用。东莨菪碱（0.03mg/kg）对空间延迟反应能力的破坏，可通过联合给予5剂剂量范围在0.03 - 0.08mg/kg的毒扁豆碱完全逆转，但仅一剂（4.0mg/kg）他克林即可逆转；在1mg/kg和3mg/kg他克林剂量下，可观察到东莨菪碱部分效应的逆转。给予4剂剂量范围在0.001 - 0.03mg/kg的毒扁豆碱后，视觉识别记忆得到增强。他克林对整个动物组的作用不显著，但使用0.8mg/kg剂量时表现出改善趋势。我们的研究结果表明，在灵长类动物中，作为认知增强剂，他克林并不比毒扁豆碱有更优越的表现。
