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[腰椎间盘源性疼痛。椎间盘退变与微创介入治疗]

[Lumbar discogenic pain. Disk degeneration and minimally invasive interventional therapies].

作者信息

Kosharskyy Boleslav, Rozen Dima

机构信息

Mount Sinai Hospital, New York, USA.

出版信息

Anasthesiol Intensivmed Notfallmed Schmerzther. 2007 Apr;42(4):262-7. doi: 10.1055/s-2007-980027.

DOI:10.1055/s-2007-980027
PMID:17457773
Abstract

Discogenic pain has been responsible for a countless number of missed workdays and millions if not billions of dollars of lost revenue. Minimally invasive interventional therapies of the discogenic back pain gained significant acceptance among the proceduralists. The centuries old dilemma of discogenic low back pain has by no means been answered. We know today that discogenic low back pain has a multitude of causes. The leaking "chemical soup" within the nucleus pulposus is certainly responsible for causing inflammation and thus pain. However, neuropeptides released from peripheral endings of nociceptive afferents are also inflammatory mediators and pain generators. The nerves innervating the discs have been identified and in many cases denervated with good results. These nerves from posterior to anterior include the sinuvertebral nerve, the rami communicantes, and the sympathetic trunk. Diagnosing discogenic low back pain is the key to successful treatment. Classically this should be a low back pain in a "band-like" distribution without radiculopathy that is worse in the morning, worse with Valsalva, and aggravated by standing in flexion. Provocative discography with manometric monitoring is essential in aiding the diagnosis. Once the diagnosis is confirmed, a multitude of invasive therapy may be offered including: L2 root sleeve blocks, intradiscal RFTC, RFTC of the rami communicantes, or Comparative data on the effectiveness of the above-mentioned procedures is lacking and may in fact be an excellent topic for future discussion.

摘要

椎间盘源性疼痛导致了无数工作日的缺勤,以及数百万甚至可能高达数十亿美元的收入损失。椎间盘源性下背痛的微创介入治疗在手术医生中得到了广泛认可。这个存在了数百年的椎间盘源性下背痛难题远未得到解决。如今我们知道,椎间盘源性下背痛有多种成因。髓核内渗漏的“化学物质混合物”肯定会引发炎症,进而导致疼痛。然而,伤害性传入神经外周末梢释放的神经肽也是炎症介质和疼痛产生源。支配椎间盘的神经已被识别出来,并且在许多情况下,对这些神经进行去神经支配取得了良好效果。这些从后向前的神经包括窦椎神经、交通支和交感干。诊断椎间盘源性下背痛是成功治疗的关键。典型的情况是,这种下背痛呈“带状”分布,无神经根病,晨起时加重,做瓦尔萨尔瓦动作时加重,站立并屈曲时加剧。在压力监测下进行激发性椎间盘造影对于辅助诊断至关重要。一旦确诊,可提供多种侵入性治疗方法,包括:L2神经根袖阻滞、椎间盘内射频热凝术、交通支射频热凝术,或者……目前缺乏上述手术有效性的对比数据,实际上这可能是未来讨论的一个绝佳话题。

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