Inui Ayano, Komatsu Haruki, Sogo Tsuyoshi, Nagai Toshiro, Abe Kenji, Fujisawa Tomoo
Department of Pediatrics, Yokohama Sakae Kyosai Hospital, Katsura-cho 132, Sakae-ku, Yokohama, Kanagawa, Japan.
J Med Virol. 2007 Jun;79(6):670-5. doi: 10.1002/jmv.20884.
The genotype distribution of hepatitis B virus (HBV) was investigated in 118 children in Japan. One hundred and sixteen children (98%) had chronic HBV infection, and the remainder had acute hepatitis. Genotyping of HBV was determined by PCR and sequencing analysis in the S gene. Genotype C (86%) was the most frequent, followed by genotype B (9%), D (2.5%), and A (1.0%). Transmission routes of HBV to children were from mothers in 91 patients (77%), fathers in 8 (6.5%), mother or father in 1 (1%), family members other than the parents in 5 (4%), and unknown in 13 (11.5%). The relationship between routes of HBV transmission and HBV genotypes was studied. Eighty-eight (97%) of 91 children of mother-to-infant transmission were genotype C, while 13 (49%) of 27 children of the routes other than the mother to infant transmission were genotype C. The number of children with genotype C who were infected from their mothers was significantly higher than those with genotype B, D, or A (P < 0.01). In conclusion, HBV genotypes influence not only clinical characteristics but also the mechanisms of inter-personal HBV transmission.
在日本的118名儿童中对乙型肝炎病毒（HBV）的基因型分布进行了调查。116名儿童（98%）患有慢性HBV感染，其余儿童患有急性肝炎。通过PCR和S基因测序分析确定HBV的基因型。C基因型（86%）最为常见，其次是B基因型（9%）、D基因型（2.5%）和A基因型（1.0%）。HBV传播给儿童的途径中，91例（77%）来自母亲，8例（6.5%）来自父亲，1例（1%）来自母亲或父亲，5例（4%）来自父母以外的家庭成员，13例（11.5%）传播途径不明。研究了HBV传播途径与HBV基因型之间的关系。91例母婴传播儿童中有88例（97%）为C基因型，而27例母婴传播以外途径感染的儿童中有13例（49%）为C基因型。从母亲感染的C基因型儿童数量显著高于B、D或A基因型儿童（P<0.01）。总之，HBV基因型不仅影响临床特征，还影响人际间HBV传播机制。
