缺氧、基因表达与转移。

Hypoxia, gene expression, and metastasis.

作者信息

Chan Denise A, Giaccia Amato J

机构信息

Department of Radiation Oncology, Division of Cancer and Radiation Biology, Stanford University School of Medicine, Stanford, CA 94305-5152, USA.

出版信息

Cancer Metastasis Rev. 2007 Jun;26(2):333-9. doi: 10.1007/s10555-007-9063-1.

DOI:10.1007/s10555-007-9063-1

PMID:17458506

Abstract

Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

摘要

缺氧给癌症治疗带来了诸多问题。缺氧肿瘤对化疗和放疗更具抗性。此外，缺氧会诱导许多导致肿瘤侵袭性、恶性程度和转移增加的基因。本节将讨论缺氧介导的基因表达所增强的转移潜能。特别关注了近期对参与转移关键步骤的特定基因的研究，包括细胞外基质相互作用、迁移和增殖。