Casale R, Colantonio D, Cialente M, Colorizio V, Barnabei R, Pasqualetti P
Department of Internal Medicine and Public Health, School of Medicine and Surgery, Chair of Medical Pathology, University of L'Aquila, Italy.
Respiration. 1991;58(3-4):198-203. doi: 10.1159/000195926.
Pulmonary function was evaluated by FEV1, FVC, PEF, MEF50%FVC, MEF25%FVC and MMEF in relation with passive smoking exposure in 143 children aged 6-11 years (mean age = 8.5 +/- 1.6). Passive smoking exposure was evaluated by a questionnaire and by measurement of urinary cotinine levels. Children were divided into different groups: no exposure, low exposure and high exposure. The mean values of each pulmonary function test were compared between the groups and between the different evaluations by Student's test. The evaluation of passive smoking exposure by questionnaire and by urinary cotinine levels separated homogeneous groups of children. The urinary cotinine levels were significantly lower in the non-exposed children than in the other groups (p less than 0.001). Pulmonary function tests, especially MEF50%FVC, MEF25%FVC and MMEF were significantly reduced in exposed subjects (p less than 0.05). These alterations are an index of early involvement of the small airways also in passive smokers. The greater the exposure to passive smoking, the lower the values of the pulmonary function tests.
对143名6至11岁（平均年龄 = 8.5±1.6岁）儿童的第一秒用力呼气量（FEV1）、用力肺活量（FVC）、呼气峰值流速（PEF）、50%用力肺活量时的最大呼气中期流速（MEF50%FVC）、25%用力肺活量时的最大呼气中期流速（MEF25%FVC）和最大呼气中期流速（MMEF）与被动吸烟暴露情况进行了肺功能评估。通过问卷调查和测量尿可替宁水平来评估被动吸烟暴露情况。儿童被分为不同组：无暴露组、低暴露组和高暴露组。通过学生检验比较了各组之间以及不同评估之间每项肺功能测试的平均值。通过问卷调查和尿可替宁水平对被动吸烟暴露情况的评估将儿童分成了同类组。未暴露儿童的尿可替宁水平显著低于其他组（p < 0.001）。暴露组受试者的肺功能测试，尤其是MEF50%FVC、MEF25%FVC和MMEF显著降低（p < 0.05）。这些改变是小气道早期受累的指标，在被动吸烟者中也是如此。被动吸烟暴露程度越高，肺功能测试值越低。
