Kniestedt C, Romppainen T, Gloor B P, Stürmer J
Augenklinik, Kantonspital Winterthur, Winterthur, Schweiz.
Klin Monbl Augenheilkd. 2007 Apr;224(4):255-9. doi: 10.1055/s-2007-962939.
Ibopamine is an alpha-adrenergic agent and causes an elevation of intraocular pressure in eyes with increased outflow resistance. It has been proposed as a test substance for the detection of early ocular hydrodynamic disorders.
A total of 64 normal-tension glaucoma suspect eyes without anti-hypertensive treatment were enrolled. A daily pressure curve was registered with measurements at 7:00 am, 8:00 am, 12:00 am, 17:00 pm using an applanation tonometer and a contour tonometer followed by instillation of ibopamine 2% in both eyes. Tonometry was performed every 15 minutes during the following hour. An IOP increase of > 2.0 mmHg was considered positive.
The positive test group showed a significant pressure increase from 18.04 to 22.06 mmHg. Ocular pulse amplitude increased from 2.96 to 3.97 mmHg and was positively correlated with the pressure. Intraocular pressure was unchanged in the negative test group. Central corneal thickness was not significantly different in the two groups (p = 0.32).
Ibopamine 2% eye drops have a positive pressure effect in 50% of suspected normal-tension glaucoma eyes and may differentiate between eyes with normal trabecular outflow capacity and eyes with increased resistance in the trabecular meshwork that are prone to pressure peaks and deterioration to glaucoma.
异波帕明是一种α-肾上腺素能药物，可使房水流出阻力增加的眼睛眼压升高。它已被提议作为检测早期眼部流体动力学障碍的测试物质。
共纳入64只未经降压治疗的正常眼压性青光眼可疑眼。使用压平眼压计和轮廓眼压计在上午7:00、8:00、12:00和下午17:00进行测量，记录每日眼压曲线，随后双眼滴入2%异波帕明。在接下来的一小时内，每15分钟进行一次眼压测量。眼压升高>2.0 mmHg被认为是阳性。
阳性测试组眼压从18.04 mmHg显著升高至22.06 mmHg。眼动脉搏动幅度从2.96 mmHg增加至3.97 mmHg，且与眼压呈正相关。阴性测试组眼压无变化。两组中央角膜厚度差异无统计学意义（p = 0.32）。
2%异波帕明滴眼液对50%的可疑正常眼压性青光眼眼有眼压升高作用，可能有助于区分小梁网房水流出能力正常的眼睛和小梁网阻力增加、易出现眼压峰值并发展为青光眼的眼睛。
