使用铜催化对1,4 - 环己二烯基三异丙氧基硅烷进行去对称化反应。
Desymmetrization of 1,4-cyclohexadienyltriisopropoxysilane using copper catalysis.
作者信息
Umeda Rui, Studer Armido
机构信息
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstrasse 40, 48149 Münster, Germany.
出版信息
Org Lett. 2007 May 24;9(11):2175-8. doi: 10.1021/ol070689d. Epub 2007 Apr 26.
PMID:17458975
Abstract
The first catalytic desymmetrization in the field of allylsilane chemistry is presented. Desymmetrization of cyclohexadienyltriisopropoxysilane is achieved using coppper catalysis. High diastereo- and enantioselectivities are obtained, and the product dienes are highly valuable building blocks for natural product synthesis.
摘要
本文展示了烯丙基硅烷化学领域的首例催化去对称化反应。通过铜催化实现了环己二烯基三异丙氧基硅烷的去对称化。反应获得了高非对映选择性和对映选择性，并且产物二烯是天然产物合成中非常有价值的结构单元。
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