Longobardi Teresa, Bernstein Charles N
University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and Department of Medicine, Winnipeg, Manitoba, Canada.
Am J Gastroenterol. 2007 Aug;102(8):1683-91. doi: 10.1111/j.1572-0241.2007.01232.x. Epub 2007 Apr 24.
We tested the hypothesis of nonlinear longitudinal trends in health-care utilization by individuals with Crohn's disease (CD) and ulcerative colitis (UC) in Manitoba.
Administrative databases were used to report resource use in 2000/1. A total of 5,485 cases of CD and UC and 45,279 matched controls were separated into incident cases (0-2 yr of disease), cases with longstanding disease (3-10 yr), and cases with very longstanding disease (>10 yr). Relative risk ratios (RRR) indicating the likelihood of resource use, given disease duration, were computed using multinomial logistic regression analysis. Sensitivity analysis was conducted to test the robustness of results to altering the disease duration cutoffs.
Independent of disease duration, in general, outpatient utilization was over twice as likely among IBD cases compared with controls whether or not the contact was made for IBD-specific reasons. The likelihood of utilization was greatest among incident cases for outpatient visits with an internist (RRR 6.16, 95% CI 5.11-7.43) and surgical visits (RRR 3.78, 95% CI 3.14-4.55). Inpatient stays for IBD-specific reasons in general were considered dependent on disease duration; in particular, there was a fourfold higher likelihood for the incident cases relative to their controls. For non-IBD-specific reasons, IBD cases were 1.5 times as likely to have inpatient stays, regardless of disease duration.
Our results suggest that within the first 2 yr from disease diagnosis the most costly resources were employed. We can likely measure the greatest proportion of treatment effects on resource use within a relatively short period.
我们检验了曼尼托巴省克罗恩病(CD)和溃疡性结肠炎(UC)患者医疗保健利用呈非线性纵向趋势的假设。
利用行政数据库报告2000/1年度的资源使用情况。总共5485例CD和UC病例以及45279例匹配对照被分为新发病例(病程0至2年)、长期患病病例(病程3至10年)和极长期患病病例(病程>10年)。使用多项逻辑回归分析计算给定病程下资源使用可能性的相对风险比(RRR)。进行敏感性分析以检验结果对改变病程临界值的稳健性。
总体而言,无论接触是否因IBD特异性原因,IBD病例的门诊利用可能性是对照的两倍多。在内科门诊就诊(RRR 6.16,95%可信区间5.11 - 7.43)和外科就诊(RRR 3.78,95%可信区间3.14 - 4.55)方面,新发病例的利用可能性最大。因IBD特异性原因的住院一般被认为取决于病程;特别是,新发病例相对于其对照的住院可能性高出四倍。对于非IBD特异性原因,无论病程如何,IBD病例住院的可能性是对照的1.5倍。
我们的结果表明,在疾病诊断后的头2年内使用了最昂贵的资源。我们可能在相对较短的时间内就能衡量治疗对资源使用影响的最大比例。