Bajaj V, Langtry J A A
Department of Dermatology, University Hospital of North Durham, Durham DH1 5TW, UK.
Br J Dermatol. 2007 Jul;157(1):118-21. doi: 10.1111/j.1365-2133.2007.07884.x. Epub 2007 Apr 25.
Idiopathic hyperhidrosis may be a disabling condition causing emotional stress and negative impact on a patient's quality of life. Oral anticholinergics are one of the treatments available. There are few published data on the use of the anticholinergic drug glycopyrronium bromide (glycopyrrolate) given orally in the treatment of hyperhidrosis.
To report a retrospective analysis describing the treatment responses, doses and side-effects of oral glycopyrrolate in the treatment of idiopathic hyperhidrosis.
Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis.
Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate. However, treatment was limited by side-effects in around one third of patients.
A prospective clinical study to compare the efficacy and side-effects of oral anticholinergics is warranted.
特发性多汗症可能是一种致残性疾病，会导致情绪压力并对患者的生活质量产生负面影响。口服抗胆碱能药物是可用的治疗方法之一。关于口服抗胆碱能药物格隆溴铵（胃长宁）用于治疗多汗症的已发表数据很少。
报告一项回顾性分析，描述口服格隆溴铵治疗特发性多汗症的治疗反应、剂量和副作用。
回顾24例患者的病历，其中9例为全身性多汗症，15例为局限性多汗症。
19例可评估患者中有15例（79%）对口服格隆溴铵有反应。然而，约三分之一的患者因副作用而限制了治疗。
有必要进行一项前瞻性临床研究，以比较口服抗胆碱能药物的疗效和副作用。
