Honma Y, Arai I, Futaki N, Hashimoto Y, Sugimoto M, Sakurai T, Nakaike S
Department of Pharmacology, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Br J Dermatol. 2007 Jun;156(6):1178-87. doi: 10.1111/j.1365-2133.2007.07882.x. Epub 2007 Apr 25.
Atopic dermatitis is a chronic inflammatory disease characterized by severe pruritus, and cutaneous barrier disruption by scratching contributes to further aggravation of the condition. We have previously shown that indomethacin delayed recovery from the effects of cutaneous barrier disruption caused by mechanical scratching in mice.
This study was designed to assess the role of cyclooxygenase (COX)-1 and COX-2 inhibitors on recovery from the effects of cutaneous barrier disruption induced by mechanical scratching in mice.
We examined the effects of SC-560 (a COX-1-selective inhibitor) or NS-398 (a COX-2-selective inhibitor) on recovery from the effects of cutaneous barrier disruption in mice induced by a wire brush, in terms of the skin prostaglandin (PG) levels.
While SC-560 significantly delayed recovery from the effects of cutaneous barrier disruption, NS-398 had no such effect. SC-560 was significantly more effective than NS-398 in reducing skin PG levels at 6 and 24 h after cutaneous barrier disruption. SC-560 strongly inhibited biosynthesis of cutaneous PGD(2) to a greater extent than that of other PGs.
COX-1-coupled PGD(2) biosynthesis may be an important factor in the recovery of cutaneous barrier disruption.
特应性皮炎是一种以严重瘙痒为特征的慢性炎症性疾病，搔抓导致的皮肤屏障破坏会使病情进一步加重。我们之前已经表明，吲哚美辛会延迟小鼠因机械搔抓引起的皮肤屏障破坏的恢复。
本研究旨在评估环氧合酶（COX）-1和COX-2抑制剂对小鼠因机械搔抓引起的皮肤屏障破坏恢复的作用。
我们从皮肤前列腺素（PG）水平方面，研究了SC-560（一种COX-1选择性抑制剂）或NS-398（一种COX-2选择性抑制剂）对小鼠因钢丝刷引起的皮肤屏障破坏恢复的影响。
虽然SC-560显著延迟了皮肤屏障破坏的恢复，但NS-398没有这种作用。在皮肤屏障破坏后6小时和24小时，SC-560在降低皮肤PG水平方面比NS-398显著更有效。SC-560比其他PGs更强烈地抑制皮肤PGD2的生物合成。
COX-1偶联的PGD2生物合成可能是皮肤屏障破坏恢复的一个重要因素。
