Aresu L, D'Angelo A, Zanatta R, Valenza F, Capucchio M T
Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Via L. da Vinci 44-10095 Grugliasco, Torino, Italy.
J Comp Pathol. 2007 May;136(4):279-82. doi: 10.1016/j.jcpa.2007.02.008. Epub 2007 Apr 24.
A 2-year-old male West Highland white terrier with a 4-month history of seizures was referred for investigation. Depressed mentation, proprioceptive deficit and decreased menace response were noted at neurological examination. Post-mortem examination of the brain revealed multifocal lesions located principally in the left side of the diencephalon and mesencephalon. The lesions consisted of non-suppurative inflammation and large areas of cavitation. The clinical evaluation and histopathological findings were consistent with a diagnosis of necrotizing meningoencephalitis (NME). Immunofluorescence performed on frozen sections of kidney revealed strong smooth linear labelling of the glomerular basement membrane with anti-IgG serum as well as weaker linear labelling with anti-IgM serum. This histomorphological pattern was consistent with anti-glomerular basement membrane glomerulonephritis. The association of this type of glomerulonephritis with a necrotizing encephalitis would support the hypothesis of an immune-mediated aetiology for NME.
一只2岁雄性西高地白梗犬，有4个月的癫痫发作史，被转诊进行检查。神经学检查发现精神沉郁、本体感觉障碍和威胁反应减弱。脑部尸检显示多灶性病变，主要位于间脑和中脑左侧。病变包括非化脓性炎症和大面积空洞形成。临床评估和组织病理学发现符合坏死性脑膜脑炎（NME）的诊断。对肾脏冰冻切片进行免疫荧光检查，结果显示抗IgG血清对肾小球基底膜有强烈的平滑线性标记，抗IgM血清的线性标记较弱。这种组织形态学模式符合抗肾小球基底膜肾小球肾炎。这种类型的肾小球肾炎与坏死性脑炎的关联支持了NME免疫介导病因的假说。
