Dubus J-C, Bosdure E, Bakuridze L, Andrieu V
Unité de Médecine Infantile et CRCM Pédiatrique, CHU de La Timone-Enfants, 264, rue Saint-Pierre, 13005 Marseille, France.
Arch Pediatr. 2007 May;14(5):504-6. doi: 10.1016/j.arcped.2007.03.008. Epub 2007 Apr 24.
The revival of nebulization as a drug delivery route is real. The current delivery systems respond to the new European norms, the new mesh-vibrating nebulizers allow delivering drugs more quickly, other nebulizers, more performant because of less drug losses and of a better lung deposition of the drug, are in progress. Only 12 drugs are commercialized for nebulization. All are available in dispensaries, some requiring a first prescription by a physician working in a hospital (cystic fibrosis drugs), others requiring a prescription from only some specialists as paediatricians or pulmonologists (bronchodilators). Works are in progress concerning the diameter and shape of the drug particles (nanotechnology) and also concerning the use of nebulized drugs for a systemic effect (vaccines, insulin, cyclosporine, anticancerous agents, etc.).
