Funauchi M, Sugishima H, Minoda M, Horiuchi A
Third Department of Internal Medicine, Kinki University School of Medicine, Osaka-Sayama.
Tohoku J Exp Med. 1991 Aug;164(4):259-67. doi: 10.1620/tjem.164.259.
Interferon-gamma is one of the cytokines which have various immunoregulatory functions. In the present study, the serum interferon-gamma level was determined in autoimmune diseases. It was increased in the active cases of systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Since there was a positive correlation between the serum interferon-gamma level and the rate of peripheral mononuclear cells positive for HLA-DR antigen in systemic lupus erythematosus, circulating interferon-gamma might have a biological functions as suggested by many in vitro studies. In rheumatoid arthritis and Sjögren's syndrome, there was no correlation between the serum interferon-gamma level and the clinical findings. These data suggest that interferon-gamma might be associated with the pathogenesis of autoimmune diseases such as SLE and MCTD, and it can be one of the indices for their disease activity.
干扰素-γ是具有多种免疫调节功能的细胞因子之一。在本研究中，测定了自身免疫性疾病患者血清中的干扰素-γ水平。在系统性红斑狼疮（SLE）和混合性结缔组织病（MCTD）的活动期病例中该水平升高。由于系统性红斑狼疮患者血清干扰素-γ水平与外周血单个核细胞HLA-DR抗原阳性率之间存在正相关，循环中的干扰素-γ可能具有许多体外研究所提示的生物学功能。在类风湿关节炎和干燥综合征中，血清干扰素-γ水平与临床表现之间无相关性。这些数据表明，干扰素-γ可能与SLE和MCTD等自身免疫性疾病的发病机制有关，并且可以作为其疾病活动的指标之一。
