早期与晚期玻璃体内注射曲安奈德治疗视网膜分支静脉阻塞相关黄斑水肿的比较
Early versus late intravitreal triamcinolone acetonide for macular edema associated with branch retinal vein occlusion.
作者信息
Oh Joo Youn, Seo Je Hyun, Ahn Jae Kyoun, Heo Jang Won, Chung Hum
机构信息
Department of Ophthalmology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.
出版信息
Korean J Ophthalmol. 2007 Mar;21(1):18-20. doi: 10.3341/kjo.2007.21.1.18.
PURPOSE
To compare the effect of early versus late intravitreal injection of triamcinolone in patients with macular edema due to branch retinal vein occlusion (BRVO).
METHODS
Twenty eyes of 20 patients with macular edema from BRVO, including 10 with duration after onset of or <or= 3 months and 10 with duration of 3 months, were treated using a single intravitreal triamcinolone injection (4 mg/0.1 ml). Best-corrected visual acuity and foveal thickness by optical coherence tomography were measured 1, 3, and 6 months post-injection.
RESULTS
In patients that received treatment after a disease duration of <or= 3 months, visual acuity and foveal thickness significantly improved from baseline over 6 months of follow-up. However, in those with a duration of >3 months, improvements in visual acuity and foveal thickness, though apparent at 1 month, were not maintained at 3 and 6 months post-triamcinolone.
CONCLUSIONS
Intravitreal triamcinolone is more effective in patients with BRVO who are treated earlier.
目的
比较早期与晚期玻璃体腔内注射曲安奈德对视网膜分支静脉阻塞（BRVO）所致黄斑水肿患者的疗效。
方法
20例BRVO所致黄斑水肿患者的20只眼，其中10例发病时间小于或等于3个月，10例发病时间大于3个月，均接受单次玻璃体腔内注射曲安奈德（4mg/0.1ml）治疗。在注射后1、3和6个月测量最佳矫正视力和光学相干断层扫描测量的黄斑中心凹厚度。
结果
病程小于或等于3个月的患者，在6个月的随访中，视力和黄斑中心凹厚度较基线水平显著改善。然而，病程大于3个月的患者，虽然在注射后1个月时视力和黄斑中心凹厚度有所改善，但在曲安奈德注射后3个月和6个月时未维持改善效果。
结论
玻璃体腔内注射曲安奈德对早期治疗的BRVO患者更有效。
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