Nucci Marisa R, Drapkin Ronny, Dal Cin Paola, Fletcher Christopher D M, Fletcher Jonathan A
Department of Pathology, Divisions of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Am J Surg Pathol. 2007 May;31(5):737-43. doi: 10.1097/01.pas.0000213414.15633.4e.
"Benign metastasizing leiomyoma" is the terminology used to describe a controversial entity characterized by a proliferation of bland-appearing smooth muscle in lung or abdominopelvic lymph nodes. In this report, we describe 5 cases of pulmonary-based smooth muscle tumors that are clinically and histologically consistent with this entity, and in which we identified consistent chromosomal aberrations (19q and 22q terminal deletion in all cases). This cytogenetic profile is found in approximately 3% of uterine leiomyoma, but has not been described in other types of benign or malignant neoplasia. These findings suggest that the nodular pulmonary smooth muscle proliferations termed "benign metastasizing leiomyoma," are a genetically distinct entity, which likely originate from a biologically distinctive subset of uterine leiomyoma.
“良性转移性平滑肌瘤”是用于描述一种有争议的实体的术语，其特征为肺或腹盆腔淋巴结中出现外观温和的平滑肌增生。在本报告中，我们描述了5例基于肺部的平滑肌瘤病例，这些病例在临床和组织学上与该实体一致，并且我们在其中发现了一致的染色体畸变（所有病例均存在19号染色体长臂和22号染色体长臂末端缺失）。这种细胞遗传学特征在约3%的子宫平滑肌瘤中可见，但在其他类型的良性或恶性肿瘤中尚未见描述。这些发现提示，被称为“良性转移性平滑肌瘤”的结节性肺平滑肌瘤增生是一种基因上独特的实体，可能起源于子宫平滑肌瘤中一个生物学上独特的亚群。
