Quaglietta Lucia, te Velde Anje, Staiano Annamaria, Troncone Riccardo, Hommes Daan W
Department of Pediatrics, University Federico II, Naples, Italy.
J Pediatr Gastroenterol Nutr. 2007 May;44(5):529-39. doi: 10.1097/MPG.0b013e31803815ee.
Crohn disease (CD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Its etiology remained obscure until recently, when, through an overwhelming body of research, the main theme of its origin became clear. CD develops in individuals who carry risk alleles for the disease that can cause a loss of physiological tolerance to commensal bacteria. As a consequence, immune responses develop that activate a whole range of immunocompetent cells, resulting in the secretion of proinflammatory mediators that ultimately cause mucosal breaks and the formation of ulceration, edema, and loss of proper function.
克罗恩病（CD）是一种胃肠道的慢性复发性炎症性疾病。直到最近，其病因一直不明，然而，通过大量研究，其起源的主要脉络已变得清晰。携带该疾病风险等位基因的个体易患CD，这些基因会导致对共生菌的生理耐受性丧失。结果，免疫反应发生，激活一系列免疫活性细胞，导致促炎介质分泌，最终引起黏膜破损以及溃疡、水肿的形成和正常功能丧失。
