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重叠Neuroform支架诱发梭形颅内动脉瘤血栓形成:病例报告

Thrombosis of a fusiform intracranial aneurysm induced by overlapping neuroform stents: case report.

作者信息

Ansari Sameer A, Lassig Jeffrey P, Nicol Ewen, Thompson B Gregory, Gemmete Joseph J, Gandhi Dheeraj

出版信息

Neurosurgery. 2007 May;60(5):E950-1; discussion E950-1. doi: 10.1227/01.NEU.0000255427.08926.DC.

Abstract

OBJECTIVE

To present a case of a true fusiform basilar artery aneurysm that underwent spontaneous thrombosis after placement of two overlapping Neuroform stents (Boston Scientific/Target, Fremont, CA).

CLINICAL PRESENTATION

A 45-year-old woman with transient syncopal episodes experienced a fall and presented to the emergency room. Incidentally, a non-contrast head computed tomographic scan and digital subtraction angiography demonstrated an unruptured, fusiform mid-basilar artery aneurysm.

INTERVENTION

Endovascular treatment was initiated by using a stent-assisted coil embolization technique with placement of a self-expanding, dedicated intracranial, Neuroform stent in the basilar artery across the aneurysm's fusiform neck. Attempts to access the aneurysm for coil embolization resulted in transient migration of the stent into the aneurysm sac. A second Neuroform stent was advanced in telescoping fashion for salvage and stable coverage across the entire aneurysm; therefore, coil embolization was deferred to allow stent endothelialization. After 6 weeks on dual antiplatelet therapy, the patient presented with transient ischemic symptoms suggesting top of the basilar artery syndrome. Subsequent magnetic resonance imaging scans and angiography indicated circumferential thrombus formation in the aneurysm sac but patent flow in the basilar artery. A computed tomographic scan at 6 months and digital subtraction angiography at 12 months confirmed complete thrombosis of the fusiform mid-basilar artery aneurysm with basilar artery reconstruction.

CONCLUSION

Overlapping Neuroform stents may induce spontaneous thrombosis of intracranial aneurysms and facilitate parent artery reconstruction through flow remodeling and stent endothelialization. Double stent placement may be a viable option in dissecting or fusiform intracranial aneurysms that are not amenable to open surgical treatment or endovascular coil embolization.

摘要

目的

介绍一例真性梭形基底动脉动脉瘤病例,该动脉瘤在置入两个重叠的Neuroform支架(波士顿科学公司/Target,弗里蒙特,加利福尼亚州)后发生自发性血栓形成。

临床表现

一名45岁有短暂晕厥发作的女性摔倒后被送往急诊室。偶然发现,头部非增强计算机断层扫描和数字减影血管造影显示一个未破裂的梭形基底动脉中段动脉瘤。

干预措施

采用支架辅助弹簧圈栓塞技术进行血管内治疗,在基底动脉横跨动脉瘤梭形颈部处置入一个自膨式专用颅内Neuroform支架。尝试进入动脉瘤进行弹簧圈栓塞时,支架短暂移入动脉瘤腔内。以套叠方式推进第二个Neuroform支架以挽救并稳定覆盖整个动脉瘤;因此,推迟弹簧圈栓塞以等待支架内皮化。在接受6周双重抗血小板治疗后,患者出现提示基底动脉尖综合征的短暂缺血症状。随后的磁共振成像扫描和血管造影显示动脉瘤腔内形成环形血栓,但基底动脉血流通畅。6个月时的计算机断层扫描和12个月时的数字减影血管造影证实梭形基底动脉中段动脉瘤完全血栓形成且基底动脉重建。

结论

重叠的Neuroform支架可能诱发颅内动脉瘤的自发性血栓形成,并通过血流重塑和支架内皮化促进载瘤动脉重建。对于不适合开放手术治疗或血管内弹簧圈栓塞的夹层或梭形颅内动脉瘤,放置双支架可能是一种可行的选择。

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