Seeberger Peter H, Werz Daniel B
Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland.
Nature. 2007 Apr 26;446(7139):1046-51. doi: 10.1038/nature05819.
Our understanding of the different glycoconjugates present on cells, proteins and entire organisms is lagging far behind advances in genomics and proteomics. Carbohydrate sequencing and the synthesis of defined oligosaccharides are two key technologies that have contributed to progress in glycomics research. Synthetic tools and high-throughput experiments such as carbohydrate arrays are beginning to affect biological research. These techniques are now being applied to the development of carbohydrate-based diagnostics, vaccines and therapeutics.
我们对细胞、蛋白质及整个生物体上存在的不同糖缀合物的了解，远远落后于基因组学和蛋白质组学的进展。碳水化合物测序和特定寡糖的合成是推动糖组学研究取得进展的两项关键技术。合成工具和诸如碳水化合物阵列之类的高通量实验正开始影响生物学研究。这些技术目前正应用于基于碳水化合物的诊断、疫苗和治疗药物的开发。
