Kucharewicz I, Bodzenta-Lukaszyk A, Szymanski W, Mroczko B, Szmitkowski M
Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
J Investig Allergol Clin Immunol. 2007;17(2):65-9.
Increased serum tryptase has been linked to the severity of the reaction after Hymenoptera stings. The aim of the study was to measure basal tryptase levels in patients with Hymenoptera venom allergy and investigate the possible correlation between these levels and the severity of sting reaction.
One hundred nine patients were included in the study. Sixty-three were wasp venom-allergic and 46 were honey bee venom-allergic. Basal serum tryptase levels were measured by UniCAP.
Basal serum tryptase levels were elevated in 12 (11%) of the 109 patients. Levels were 5.14 pg/L (3.62-5.84), 5.3 microg/L (2.94-6.54), 5.18 microg/L (3.71-6.25), and 6.98 microg/L (4.78-12.6), for patients with sting reactions of grade I, II, III and IV (as classified by Mueller), respectively. Basal serum tryptase levels correlated significantly with the sting reaction severity (r = 0.2752; P = .004) and with age (r = 0.2906; P = .002). Sting reaction severity also correlated with age (r = 0.3654; P = .001).
Basal serum tryptase levels were found to be elevated in 11% of venom allergic patients and correlated significantly with both sting reaction severity and age.
血清类胰蛋白酶水平升高与膜翅目昆虫叮咬后反应的严重程度相关。本研究的目的是测量膜翅目昆虫毒液过敏患者的基础类胰蛋白酶水平，并调查这些水平与叮咬反应严重程度之间的可能相关性。
109名患者纳入本研究。其中63名对黄蜂毒液过敏，46名对蜜蜂毒液过敏。采用UniCAP法测量基础血清类胰蛋白酶水平。
109名患者中有12名（11%）基础血清类胰蛋白酶水平升高。根据Mueller分类法，I、II、III和IV级叮咬反应患者的基础血清类胰蛋白酶水平分别为5.14 pg/L（3.62 - 5.84）、5.3 μg/L（2.94 - 6.54）、5.18 μg/L（3.71 - 6.25）和6.98 μg/L（4.78 - 12.6）。基础血清类胰蛋白酶水平与叮咬反应严重程度显著相关（r = 0.2752；P = 0.004），与年龄也显著相关（r = 0.2906；P = 0.002）。叮咬反应严重程度与年龄也相关（r = 0.3654；P = 0.001）。
发现11%的毒液过敏患者基础血清类胰蛋白酶水平升高，且与叮咬反应严重程度和年龄均显著相关。
