Osipenko M F, Bikbulatova E A
Ter Arkh. 2007;79(2):26-31.
To study prevalence of colon diverticula (CD) and phenotypical features of patients with this anomaly.
At the first stage of the study we analysed colon x-ray evidence for 3 years to assess prevalence of CD. At the second stage we examined 59 patients with CD. Sixty patients with idiopathic constipation and 48 patients with irritable colon syndrome served control.
We discovered the following independent factors associated with a high CD risk: history of CD in the relatives of the patients (OR 24.6; 95% CI 5.23-116.23; p = 0.0001) and age of the patient (OR 2.5; 95% CI 1.03-1.13; p = 0.0010). Age-dependent CD occurrence, similar anomalies in the relatives, other structural gastrointestinal anomalies in them, hyperaminociduria suggest that CD represent a metabolic involutionary process with hereditary predisposition. CD manifested clinically with abdominal pain and problems with colon passage. Abdominal pain related to defecation occurred with low pain threshold to extension. Abdominal pain risk in CD patients is significantly associated with intestinal infections (OR 4.56; 95% CI 1.09-18.97; chi-square = 4.34; p = 0.0372) and connective tissue dysplasia syndrome (OR 2.21; 95% CI 1.23-3.95; chi-square = 7.08; p = 0.0078). Independent risk factors of constipation in CD are non-morning defecation (OR 8.68; 95% CI 1.55-48.51; chi-square = 6.06; p = 0.0138), connective tissue dysplasia syndrome (OR 1.77; 95% CI 1.0-3.20; chisquare = 3.65; p = 0.0501), sedentary life style (OR 7.42; 94% CI 1.24 - 44.57; chi-square = 4.81; p = 0.0284).
Incomplete CD reflect colon involution. Abdominal pain associated with defecation has much in common with irritable colon syndrome.
研究结肠憩室（CD）的患病率以及患有这种异常的患者的表型特征。
在研究的第一阶段，我们分析了3年的结肠X光证据以评估CD的患病率。在第二阶段，我们检查了59例CD患者。60例特发性便秘患者和48例肠易激综合征患者作为对照。
我们发现以下与高CD风险相关的独立因素：患者亲属中有CD病史（OR 24.6；95%可信区间5.23 - 116.23；p = 0.0001）以及患者年龄（OR 2.5；95%可信区间1.03 - 1.13；p = 0.0010）。年龄依赖性CD的发生、亲属中的类似异常、他们身上的其他胃肠道结构异常、高氨基酸尿症表明CD代表一种具有遗传易感性的代谢性退化过程。CD在临床上表现为腹痛和结肠排便问题。与排便相关的腹痛在伸展时疼痛阈值较低时发生。CD患者的腹痛风险与肠道感染（OR 4.56；95%可信区间1.09 - 18.97；卡方 = 4.34；p = 0.0372）和结缔组织发育异常综合征（OR 2.21；95%可信区间1.23 - 3.95；卡方 = 7.08；p = 0.0078）显著相关。CD患者便秘的独立危险因素是非晨起排便（OR 8.68；95%可信区间1.55 - 48.51；卡方 = 6.06；p = 0.0138）、结缔组织发育异常综合征（OR 1.77；95%可信区间1.0 - 3.20；卡方 = 3.65；p = 0.0501）、久坐的生活方式（OR 7.42；94%可信区间1.24 - 44.57；卡方 = 4.81；p = 0.0284）。
不完全性CD反映结肠退化。与排便相关的腹痛与肠易激综合征有许多共同之处。
