Attahiru U S, Iyaniwura T T, Adaudi A O, Bonire J J
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Vet Hum Toxicol. 1991 Oct;33(5):499-502.
The effects of a moderate but prolonged exposure of rats to tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), as might be encountered as residues in yam peel diets, were investigated in rats. These subchronic toxicity studies (16, 8, or 4 mg TBTA/kg and 20, 10 or 5 mg TPTA/kg) showed histopathologic lesions in lungs, liver, intestine and kidney. The hematologic parameters in the groups treated with either compound fell within the normal range for the rats. However, there was a reduction in mean lymphocyte count for rats receiving 10 or 20 mg TPTA/kg, and a reduction in monocyte count in the 20 mg TPTA/kg group. These data indicate a need for further toxicologic studies and cautionary measures to avoid ingestion, inhalation or contamination of dietary materials by these fungicides.
研究了大鼠适度但长期接触醋酸三丁基锡（TBTA）和醋酸三苯基锡（TPTA）的影响，这两种物质可能作为山药皮饮食中的残留物被大鼠接触到。这些亚慢性毒性研究（16、8或4毫克TBTA/千克以及20、10或5毫克TPTA/千克）显示，大鼠的肺、肝、肠和肾出现了组织病理学损伤。用这两种化合物处理的组中的血液学参数均在大鼠的正常范围内。然而，接受10或20毫克TPTA/千克的大鼠平均淋巴细胞计数减少，在20毫克TPTA/千克组中单核细胞计数减少。这些数据表明需要进一步进行毒理学研究并采取预防措施，以避免这些杀菌剂摄入、吸入或污染饮食材料。
