Attahiru U S, Iyaniwura T T, Adaudi A O, Bonire J J
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Vet Hum Toxicol. 1991 Dec;33(6):554-6.
Two organotin compounds, tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), that have antifungal potentials and are intended for use on yam root crops to prevent rot were evaluated for acute mammalian toxicity in rats. The median lethal doses po were 297.54 mg TBTA/kg and 402.38 mg TPTA/kg. Both compounds produced significant central nervous system and respiratory depressions at single doses of 200 mg TBTA/kg or 300 mg TPTA/kg. The histopathological findings due to TBTA included pulmonary, hepatic and renal congestion, brain hemorrhages, and destruction of the intestinal mucosa. TPTA produced brain congestion, and hepatic and pulmonary petechial and generalized hemorrhages.
对两种具有抗真菌潜力、旨在用于山药块根作物以防止腐烂的有机锡化合物——醋酸三正丁基锡（TBTA）和醋酸三苯基锡（TPTA），进行了大鼠急性哺乳动物毒性评估。经口给药的半数致死剂量分别为TBTA 297.54毫克/千克和TPTA 402.38毫克/千克。在单剂量为200毫克TBTA/千克或300毫克TPTA/千克时，两种化合物均产生了显著的中枢神经系统和呼吸抑制。TBTA导致的组织病理学结果包括肺、肝和肾充血、脑出血以及肠黏膜破坏。TPTA导致脑充血以及肝和肺的瘀点性出血和全身性出血。
