Zhang J L, Srivastava R S, Misra R D K
Center for Structural and Functional Materials and Department of Chemical Engineering, University of Louisiana at Lafayette, Lafayette, Louisiana 70504, USA.
Langmuir. 2007 May 22;23(11):6342-51. doi: 10.1021/la0636199. Epub 2007 Apr 27.
We describe here the synthesis of a novel magnetic drug-targeting carrier characterized by a core-shell structure. The core-shell carrier combines the advantages of a magnetic core and the stimuli-responsive property of the thermosensitive biodegradable polymer shell (e.g., an on-off mechanism responsive to external temperature change). The composite nanoparticles are approximately 8 nm in diameter with approximately 3 nm shell. The lower critical solution temperature (LCST) is approximately 38 degrees C as determined by UV-vis absorption spectroscopy. The carrier is composed of cross-linked dextran grafted with a poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) [dextran-g-poly(NIPAAm-co-DMAAm)] shell and superparamagnetic Fe3O4 core. Fourier transform infrared spectroscopy (FTIR) confirmed the composition of the carrier. The synthesized magnetic carrier system has potential applications in magnetic drug-targeting delivery and magnetic resonance imaging.
我们在此描述一种具有核壳结构特征的新型磁性药物靶向载体的合成。该核壳载体结合了磁芯的优点和热敏性可生物降解聚合物壳的刺激响应特性（例如，对外部温度变化的开-关机制响应）。复合纳米颗粒直径约为8 nm，壳层约为3 nm。通过紫外-可见吸收光谱法测定，其低临界溶液温度（LCST）约为38℃。该载体由接枝有聚（N-异丙基丙烯酰胺-co-N，N-二甲基丙烯酰胺）[葡聚糖-g-聚（NIPAAm-co-DMAAm）]壳层的交联葡聚糖和超顺磁性Fe3O4磁芯组成。傅里叶变换红外光谱（FTIR）证实了载体的组成。合成的磁性载体系统在磁性药物靶向递送和磁共振成像方面具有潜在应用。
