泊沙康唑成功治疗中性粒细胞减少症期间及随后异基因造血干细胞移植过程中的播散性镰刀菌病。
Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation.
作者信息
Gupta S, Almyroudis N G, Battiwalla M, Bambach B J, McCarthy P L, Proefrock A D, Ball D, Paplham P, Varma A, Kwon-Chung J, Segal B H
机构信息
Department of Medicine, School of Medicine and Biochemical Sciences, SUNY at Buffalo, Buffalo, New York, USA.
出版信息
Transpl Infect Dis. 2007 Jun;9(2):156-60. doi: 10.1111/j.1399-3062.2006.00189.x.
We report the case of a 16-year-old girl with acute myelogenous leukemia with disseminated fusariosis, who responded to salvage posaconazole therapy. She subsequently received additional cytotoxic chemotherapy and allogeneic hematopoietic stem cell transplantation with posaconazole continued as secondary prophylaxis. Despite intensive immunosuppressive therapy for graft-versus-host disease, no recrudescence of infection occurred.
我们报告了一例16岁患有急性髓性白血病并伴有播散性镰刀菌病的女孩，她对挽救性泊沙康唑治疗有反应。随后她接受了额外的细胞毒性化疗和异基因造血干细胞移植，同时继续使用泊沙康唑作为二级预防。尽管对移植物抗宿主病进行了强化免疫抑制治疗，但感染未复发。
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