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轮枝镰孢/木贼镰孢所致血液透析移植物感染

Fusarium incarnatum/equiseti hemodialysis graft infection.

作者信息

Riddell James, Woodside Kenneth J, Leavitt Matthew A, Newton Duane W, Punch Jeffery D

机构信息

Department of Internal Medicine, Division of Infectious Diseases;

Department of Surgery, Division of Transplantation, ; Current address: Department of Surgery, Division of Transplant and Hepatobiliary Surgery, University Hospitals, Case Medical Center;

出版信息

Infect Dis Rep. 2010 Nov 2;2(2):e14. doi: 10.4081/idr.2010.e14. eCollection 2010 Aug 4.

DOI:10.4081/idr.2010.e14
PMID:24470894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3892584/
Abstract

Hemodialysis graft infections typically occur as a result of contamination by skin flora at the time of insertion or become secondarily infected after high-grade bacteremia. Infection of implanted vascular devices with filamentous fungi is rare. We report a case of infection of an implanted polytetrafluoroethylene dialysis graft with Fusarium incarnatum/equiseti that did not grow in cultures of tissue but was identified by molecular means.

摘要

血液透析移植物感染通常是由于植入时皮肤菌群污染所致，或在严重菌血症后继发感染。丝状真菌感染植入性血管装置的情况较为罕见。我们报告一例由肉色镰刀菌/多隔镰刀菌感染植入的聚四氟乙烯透析移植物的病例，该真菌在组织培养中未生长，但通过分子手段得以鉴定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9e/3892584/f7fe9b6c4fea/idr-2010-2-e14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9e/3892584/6126d42397e1/idr-2010-2-e14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9e/3892584/f7fe9b6c4fea/idr-2010-2-e14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9e/3892584/6126d42397e1/idr-2010-2-e14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9e/3892584/f7fe9b6c4fea/idr-2010-2-e14-g002.jpg

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本文引用的文献

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Less-frequent Fusarium species of clinical interest: correlation between morphological and molecular identification and antifungal susceptibility.临床关注的罕见镰刀菌属物种：形态学与分子鉴定及抗真菌药敏之间的相关性
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Species distribution and in vitro antifungal susceptibility patterns of 75 clinical isolates of Fusarium spp. from northern Italy.来自意大利北部的75株镰刀菌临床分离株的物种分布及体外抗真菌药敏模式。
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Treating disseminated fusariosis: amphotericin B, voriconazole or both?治疗播散性镰刀菌病：两性霉素B、伏立康唑还是两者联用？
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Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation.泊沙康唑成功治疗中性粒细胞减少症期间及随后异基因造血干细胞移植过程中的播散性镰刀菌病。
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Successful treatment of resistant ocular fusariosis with posaconazole (SCH-56592).泊沙康唑（SCH-56592）成功治疗耐药性眼部镰刀菌病。
Am J Ophthalmol. 2007 Feb;143(2):222-227. doi: 10.1016/j.ajo.2006.10.048. Epub 2006 Dec 8.
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Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions.泊沙康唑作为基础血液系统恶性肿瘤及其他疾病患者侵袭性镰刀菌病的挽救治疗药物。
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8
Successful treatment of disseminated Fusariosis after allogeneic hematopoietic stem cell transplantation with the combination of voriconazole and liposomal amphotericin B.异基因造血干细胞移植后，伏立康唑和脂质体两性霉素B联合成功治疗播散性镰刀菌病。
J Infect. 2006 Dec;53(6):e243-6. doi: 10.1016/j.jinf.2006.02.011. Epub 2006 Apr 11.
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Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.目前可用抗真菌药物对3378株西班牙临床分离酵母和丝状真菌活性的直接比较。
Antimicrob Agents Chemother. 2006 Mar;50(3):917-21. doi: 10.1128/AAC.50.3.917-921.2006.
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Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin.伏立康唑成功治疗镰刀菌性眼内炎，伏立康唑联合卡泊芬净成功治疗曲霉菌性眼内炎。
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