Kumar R, Herbert P E, Warrens A N
Department of Immunology, Hammersmith Hospital, Imperial College of Science, Technology and Medicine, Du Cane Road, London W12 0NN, UK.
Int J Surg. 2005;3(4):268-77. doi: 10.1016/j.ijsu.2005.05.002. Epub 2005 Sep 12.
Apoptosis is a source of much research interest across many fields, including developmental biology, immunology and oncology. As the exact pathways of this process are identified, so too are potential avenues for therapeutic application. Death receptors are important in inducing apoptosis and together with their ligands have become a source of attention as potential therapeutic agents. This review provides an introduction to the role of death receptors in apoptosis, together with a look at possible areas where this information may be applied therapeutically.
细胞凋亡是包括发育生物学、免疫学和肿瘤学在内的许多领域中备受研究关注的一个课题。随着这一过程的确切途径被确定，其潜在的治疗应用途径也得以明确。死亡受体在诱导细胞凋亡中起着重要作用，它们与其配体一起，已成为备受关注的潜在治疗药物来源。本综述介绍了死亡受体在细胞凋亡中的作用，并探讨了这些信息可能在治疗中应用的潜在领域。
