Babiloni Claudio, Squitti Rosanna, Del Percio Claudio, Cassetta Emanuele, Ventriglia Maria Carla, Ferreri Florinda, Tombini Mario, Frisoni Giovanni, Binetti Giuliano, Gurzi Mariella, Salinari Serenella, Zappasodi Filippo, Rossini Paolo M
Dip Fisiologia Umana e Farmacologia, Univ La Sapienza, Rome, Italy.
Clin Neurophysiol. 2007 Jun;118(6):1244-60. doi: 10.1016/j.clinph.2007.03.016. Epub 2007 Apr 25.
The present study tested the hypothesis that the serum copper abnormalities were correlated with alterations of resting electroencephalographic (EEG) rhythms across the continuum of healthy elderly (Hold), mild cognitive impairment (MCI), and AD subjects.
Resting eyes-closed EEG rhythms delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), beta 2 (20-30Hz), and gamma (30-40Hz), estimated by LORETA, were recorded in 17 Hold, 19 MCI, 27 AD- (MMSE< or =20), and 27 AD+ (MMSE20) individuals and correlated with copper biological variables.
Across the continuum of Hold, MCI and AD subjects, alpha sources in parietal, occipital, and temporal areas were decreased, while the magnitude of the delta and theta EEG sources in parietal, occipital, and temporal areas was increased. The fraction of serum copper unbound to ceruloplasmin positively correlated with temporal and frontal delta sources, regardless of the effects of age, gender, and education.
These results sustain the hypothesis of a toxic component of serum copper that is correlated with functional loss of AD, as revealed by EEG indexes.
The present study represents the first demonstration that the fraction of serum copper unbound to ceruloplasmin is correlated with cortical delta rhythms across Hold, MCI, and AD subjects, thus unveiling possible relationships among the biological parameter, advanced neurodegenerative processes, and synchronization mechanisms regulating the relative amplitude of selective EEG rhythms.
本研究检验了以下假设，即血清铜异常与健康老年人（健康组）、轻度认知障碍（MCI）和阿尔茨海默病（AD）患者整个连续体中静息脑电图（EEG）节律的改变相关。
通过低分辨率电磁断层成像（LORETA）估计的静息闭眼EEG节律，即δ波（2 - 4Hz）、θ波（4 - 8Hz）、α1波（8 - 10.5Hz）、α2波（10.5 - 13Hz）、β1波（13 - 20Hz）、β2波（20 - 30Hz）和γ波（30 - 40Hz），在17名健康组、19名MCI患者、27名AD -（简易精神状态检查表（MMSE）≤20）和27名AD +（MMSE>20）个体中进行记录，并与铜生物学变量相关联。
在健康组、MCI和AD患者的整个连续体中，顶叶、枕叶和颞叶区域的α波源减少，而顶叶、枕叶和颞叶区域的δ波和θ波EEG源的幅度增加。与铜蓝蛋白未结合的血清铜分数与颞叶和额叶的δ波源呈正相关，不受年龄、性别和教育程度的影响。
这些结果支持了血清铜的毒性成分与AD功能丧失相关的假设，如EEG指标所示。
本研究首次证明，与铜蓝蛋白未结合的血清铜分数与健康组、MCI和AD患者的皮质δ波节律相关，从而揭示了生物学参数、晚期神经退行性过程以及调节选择性EEG节律相对振幅的同步机制之间的可能关系。
