Babiloni Claudio, Ferri Raffaele, Binetti Giuliano, Cassarino Andrea, Dal Forno Gloria, Ercolani Matilde, Ferreri Florinda, Frisoni Giovanni B, Lanuzza Bartolo, Miniussi Carlo, Nobili Flavio, Rodriguez Guido, Rundo Francesco, Stam Cornelis J, Musha Toshimitsu, Vecchio Fabrizio, Rossini Paolo M
Dipartimento di Fisiologia Umana e Farmacologia, Università degli Studi di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Brain Res Bull. 2006 Mar 15;69(1):63-73. doi: 10.1016/j.brainresbull.2005.10.013. Epub 2005 Nov 21.
Electroencephalographic (EEG) data were recorded in 69 normal elderly (Nold), 88 mild cognitive impairment (MCI), and 109 mild Alzheimer's disease (AD) subjects at rest condition, to test whether the fronto-parietal coupling of EEG rhythms is in line with the hypothesis that MCI can be considered as a pre-clinical stage of the disease at group level. Functional coupling was estimated by synchronization likelihood of Laplacian-transformed EEG data at electrode pairs, which accounts for linear and non-linear components of that coupling. Cortical rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), beta 2 (20-30Hz), and gamma (30-40Hz). Compared to the Nold subjects, the AD patients presented a marked reduction of the synchronization likelihood (delta to gamma) at both fronto-parietal and inter-hemispherical (delta to beta 2) electrodes. As a main result, alpha 1 synchronization likelihood progressively decreased across Nold, MCI, and mild AD subjects at midline (Fz-Pz) and right (F4-P4) fronto-parietal electrodes. The same was true for the delta synchronization likelihood at right fronto-parietal electrodes (F4-P4). For these EEG bands, the synchronization likelihood correlated with global cognitive status as measured by the Mini Mental State Evaluation. The present results suggest that at group level, fronto-parietal coupling of the delta and alpha rhythms progressively becomes abnormal though MCI and mild AD. Future longitudinal research should evaluate whether the present EEG approach is able to predict the cognitive decline in individual MCI subjects.
在静息状态下，对69名正常老年人（Nold）、88名轻度认知障碍（MCI）患者和109名轻度阿尔茨海默病（AD）患者进行了脑电图（EEG）数据记录，以检验EEG节律的额顶叶耦合是否符合MCI可被视为该疾病临床前期阶段这一假设。通过拉普拉斯变换后的EEG数据在电极对处的同步似然性来估计功能耦合，该同步似然性考虑了耦合的线性和非线性成分。感兴趣的皮层节律包括δ波（2 - 4Hz）、θ波（4 - 8Hz）、α1波（8 - 10.5Hz）、α2波（10.5 - 13Hz）、β1波（13 - 20Hz）、β2波（20 - 30Hz）和γ波（30 - 40Hz）。与Nold组受试者相比，AD患者在额顶叶和半球间（δ波至β2波）电极处的同步似然性（δ波至γ波）均显著降低。主要结果是，在中线（Fz - Pz）和右侧（F4 - P4）额顶叶电极处，α1波同步似然性在Nold组、MCI组和轻度AD组受试者中逐渐降低。右侧额顶叶电极（F4 - P4）处的δ波同步似然性情况也是如此。对于这些EEG频段，同步似然性与简易精神状态检查表测量的整体认知状态相关。目前的结果表明，在组水平上，δ波和α波节律的额顶叶耦合在MCI和轻度AD过程中逐渐变得异常。未来的纵向研究应评估目前的EEG方法是否能够预测个体MCI受试者的认知衰退。
