Thai To-Ha, Calado Dinis Pedro, Casola Stefano, Ansel K Mark, Xiao Changchun, Xue Yingzi, Murphy Andrew, Frendewey David, Valenzuela David, Kutok Jeffery L, Schmidt-Supprian Marc, Rajewsky Nikolaus, Yancopoulos George, Rao Anjana, Rajewsky Klaus
CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA.
Science. 2007 Apr 27;316(5824):604-8. doi: 10.1126/science.1141229.
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
微小RNA是参与多个层面生物调控的小RNA种类。通过基因敲除和转基因方法，我们发现进化上保守的微小RNA-155（miR-155）在哺乳动物免疫系统中具有重要作用，特别是在调节辅助性T细胞分化和生发中心反应以产生最佳的T细胞依赖性抗体反应方面。miR-155至少部分地通过调节细胞因子的产生来发挥这种调控作用。这些结果还表明，单个微小RNA可以在体内对哺乳动物的分化过程施加关键调控。
