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miR-155和外泌体miR-155在肿瘤血管生成中的双重作用：对癌症进展和治疗的影响

Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy.

作者信息

Hussain Qusay Mohammed, Al-Hussainy Ali Fawzi, Sanghvi Gaurav, Roopashree R, Kashyap Aditya, Anand D Alex, Panigrahi Rajashree, Shavazi Nargiz, Taher Sada Ghalib, Alwan Mariem, Jawad Mahmood, Mushtaq Hiba

机构信息

College of Pharmacy, Alnoor University, Mosul, Iraq.

College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq.

出版信息

Eur J Med Res. 2025 May 19;30(1):393. doi: 10.1186/s40001-025-02618-z.

DOI:10.1186/s40001-025-02618-z
PMID:40383762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12087080/
Abstract

Tumor angiogenesis facilitates cancer progression by supporting tumor growth and metastasis. MicroRNA-155 (miR-155) plays a pivotal role in regulating angiogenesis through both direct effects on tumor and endothelial cells and indirect modulation via exosomal communication. This review highlights miR-155's pro-angiogenic influence on endothelial cell behavior and tumor microenvironment remodeling. Additionally, exosomal miR-155 enhances intercellular communication, promoting vascularization in several cancers. Emerging therapeutic strategies include miR-155 inhibition using antagomirs, exosome-mediated delivery systems, and modulation of pathways such as JAK2/STAT3 and TGF-β/SMAD2. Targeting miR-155 represents a promising approach to hinder tumor angiogenesis and improve cancer therapy outcomes.

摘要

肿瘤血管生成通过支持肿瘤生长和转移促进癌症进展。微小RNA-155（miR-155）在调节血管生成中起关键作用，其作用方式包括对肿瘤细胞和内皮细胞的直接影响以及通过外泌体通讯的间接调节。这篇综述重点介绍了miR-155对内皮细胞行为和肿瘤微环境重塑的促血管生成影响。此外，外泌体miR-155增强细胞间通讯，促进多种癌症中的血管生成。新兴的治疗策略包括使用抗miR-155寡核苷酸抑制miR-155、外泌体介导的递送系统以及调节JAK2/STAT3和TGF-β/SMAD2等信号通路。靶向miR-155是一种有前景的方法，可阻碍肿瘤血管生成并改善癌症治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/ce5ab65d5876/40001_2025_2618_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/4265ded4a992/40001_2025_2618_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/e934a6824c36/40001_2025_2618_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/5c1b920e00ea/40001_2025_2618_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/ce5ab65d5876/40001_2025_2618_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/4265ded4a992/40001_2025_2618_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/e934a6824c36/40001_2025_2618_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/5c1b920e00ea/40001_2025_2618_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e992/12087080/ce5ab65d5876/40001_2025_2618_Fig4_HTML.jpg

相似文献

[1]
Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy.

Eur J Med Res. 2025-5-19

[2]
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Cell Death Dis. 2024-12-18

[3]
Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway.

J Exp Clin Cancer Res. 2018-10-3

[4]
Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma.

Angiogenesis. 2019-4-15

[5]
Exosomal miR-92a-3p modulates M2 macrophage polarization in colorectal cancer: implications for tumor migration and angiogenesis.

Med Oncol. 2025-3-10

[6]
MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells.

Cell Oncol (Dordr). 2017-7-24

[7]
MEG3-Mediated Oral Squamous-Cell-Carcinoma-Derived Exosomal miR-421 Activates Angiogenesis by Targeting HS2ST1 in Vascular Endothelial Cells.

Int J Mol Sci. 2024-7-10

[8]
Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma.

Carcinogenesis. 2022-8-30

[9]
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA).

Mol Cancer. 2015-7-16

[10]
Extracellular shuttling miR-21 contributes to esophageal cancers and human umbilical vein endothelial cell communication in the tumor microenvironment and promotes tumor angiogenesis by targeting phosphatase and tensinhomolog.

Thorac Cancer. 2023-11

引用本文的文献

[1]
Interplay between innate-like T-cells and microRNAs in cancer immunity.

Discov Oncol. 2025-7-28

[2]
Tumor-derived exosomes and their application in cancer treatment.

J Transl Med. 2025-7-8

本文引用的文献

[1]
Exosomal Delivery of miR-155 Inhibitor can Suppress Migration, Invasion, and Angiogenesis Via PTEN and DUSP14 in Triple-negative Breast Cancer.

Curr Med Chem. 2024-10-31

[2]
Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer.

Exp Mol Med. 2024-4

[3]
Cancer-associated fibroblast-derived exosome microRNA-21 promotes angiogenesis in multiple myeloma.

Sci Rep. 2023-6-14

[4]
Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.

Cell Signal. 2023-7

[5]
NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK.

J Cell Mol Med. 2023-4

[6]
AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis.

Int J Biol Sci. 2023

[7]
Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.

EBioMedicine. 2022-12

[8]
BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress-related tumorigenicity.

Cancer Sci. 2023-2

[9]
Nuclear receptor subfamily 3 group c member 2 (NR3C2) is downregulated due to hypermethylation and plays a tumor-suppressive role in colon cancer.

Mol Cell Biochem. 2022-11

[10]
MicroRNA-155-5p Targets NR3C2 to Promote Malignant Progression of Clear Cell Renal Cell Carcinoma.

Kidney Blood Press Res. 2022

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