Nalesso Federico, Brendolan Alessandra, Crepaldi Carlo, Cruz Dinna, de Cal Massimo, Bellomo Rinaldo, Ronco Claudio
Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.
Contrib Nephrol. 2007;156:411-8. doi: 10.1159/000102132.
Albumin-bound toxins are important in the pathophysiology of liver failure, systemic inflammatory response syndrome, and poisoning. Due to its intrinsic ability to bind molecules, albumin has been used in blood purification techniques, such as single pass albumin dialysis, the molecular adsorbent recirculating system and the Prometheus systems. Plasma filtration adsorption dialysis is the latest technology that can combine the best processes of blood/plasma purification in order to determine a selective and effective purification of molecules implicated in liver failure.
白蛋白结合毒素在肝衰竭、全身炎症反应综合征及中毒的病理生理学中具有重要意义。由于白蛋白具有内在的分子结合能力，它已被应用于血液净化技术，如单程白蛋白透析、分子吸附循环系统及普罗米修斯系统。血浆滤过吸附透析是最新技术，它能结合血液/血浆净化的最佳流程，以实现对与肝衰竭相关分子的选择性有效净化。
