染色质重塑剂在肺癌治疗中的应用。

Utilization of chromatin remodeling agents for lung cancer therapy.

作者信息

Schrump David S, Hong Julie A, Nguyen Dao M

机构信息

Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1201, USA.

出版信息

Cancer J. 2007 Jan-Feb;13(1):56-64. doi: 10.1097/PPO.0b013e31803c74cf.

DOI:10.1097/PPO.0b013e31803c74cf

PMID:17464247

Abstract

Lung cancer is a disease with enormous global medical and economic impact that remains refractory to conventional treatment modalities. Recent insights regarding mechanisms pertaining to epigenetic regulation of gene expression during malignant transformation, together with the identification of agents that modulate chromatin structure provide new opportunities for the treatment and prevention of this lethal disease.

摘要

肺癌是一种对全球医学和经济有着巨大影响的疾病，传统治疗方式对其仍然无效。最近关于恶性转化过程中基因表达的表观遗传调控机制的见解，以及对调节染色质结构的药物的鉴定，为治疗和预防这种致命疾病提供了新的机会。