Bettinardi V, Mancosu P, Danna M, Giovacchini G, Landoni C, Picchio M, Gilardi M C, Savi A, Castiglioni I, Lecchi M, Fazio F
San Raffaele Hospital Scientific Institute, IBFM-CNR, University of Milano Bicocca, Milano, Italy.
Q J Nucl Med Mol Imaging. 2007 Sep;51(3):214-23. Epub 2007 Apr 30.
To evaluate the performance of the positron emission tomography (PET)/computed tomography (CT) Discovery-STE (D-STE) scanner for lesion detectability in two-dimensional (2D) and three-dimensional (3D) acquisition.
A NEMA 2001 Image-Quality phantom with 11 lesions (7-37 mm in diameter) filled with a solution of 18F (lesion/background concentration ratio: 4.4) was studied. 2D and 3D PET scans were sequentially acquired (10 min each) in list mode (LM). Each scan was unlisted into 4, 3 and 2-min scans. Ten [18F]FDG PET oncological patient studies were also evaluated. Each patient underwent a 3D PET/CT whole body scan, followed by a 2D PET scan (4 min LM) and a 3D PET scan (4 min LM) over a single field of view. Both 2D and 3D scans were unlisted in 3 and 2-min scans. Data were evaluated quantitatively by calculating quality measurements and qualitatively by two physicians who judged lesion detectability compared to statistical variations in background activity.
Quantitative and qualitative evaluations showed the superiority of 3D over 2D across all measures of quality. In particular, lesion detectability was better in 3D than in 2D at equal scan times and 3D acquisition provided images comparable in quality to 2D in approximately half the time. Interobserver variability was lower in evaluation of 3D scans and lesion shape and volume were better depicted.
In oncological applications, the D-STE system demonstrated good performance in 2D and 3D acquisition, while 3D exhibited better image quality, data accuracy and consistency of lesion detectability, resulting in shorter scan times and higher patient throughput.
评估正电子发射断层扫描（PET）/计算机断层扫描（CT）Discovery-STE（D-STE）扫描仪在二维（2D）和三维（3D）采集中对病变的可检测性。
研究了一个填充有18F溶液（病变/背景浓度比为4.4）的含11个病变（直径7 - 37毫米）的NEMA 2001图像质量模体。以列表模式（LM）依次进行2D和3D PET扫描（各10分钟）。每次扫描被拆分为4分钟、3分钟和2分钟的扫描。还评估了10例[18F]FDG PET肿瘤患者研究。每位患者先进行一次3D PET/CT全身扫描，然后在单个视野上进行一次2D PET扫描（4分钟LM）和一次3D PET扫描（4分钟LM）。2D和3D扫描均被拆分为3分钟和2分钟的扫描。通过计算质量测量值对数据进行定量评估，并由两名医生进行定性评估，他们将病变可检测性与背景活动的统计变化进行比较。
定量和定性评估均显示，在所有质量指标上3D优于2D。特别是，在相同扫描时间下，3D的病变可检测性优于2D，且3D采集在大约一半的时间内提供了与2D质量相当的图像。在评估3D扫描时观察者间变异性较低，并且病变形状和体积得到了更好的描绘。
在肿瘤学应用中，D-STE系统在2D和3D采集中均表现出良好性能，而3D表现出更好的图像质量、数据准确性和病变可检测性的一致性，从而缩短了扫描时间并提高了患者通量。
