Alemdaroglu Fikri E, Herrmann Andreas
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Org Biomol Chem. 2007 May 7;5(9):1311-20. doi: 10.1039/b617941j. Epub 2007 Feb 21.
The combination of synthetic polymers and DNA has provided biologists, chemists and materials scientists with a fascinating new hybrid material. The challenges in preparing these molecular chimeras were overcome by different synthetic strategies that rely on coupling the nucleic acid moiety and the organic polymer in solution or on solid supports. The morphologies and functions of the bioorganic block copolymers can be controlled by the nature of the synthetic polymer segment as well as by the sequence composition and length of the DNA. Recent developments have expanded the scope and applications of these hybrid materials in a number of different areas including biology and medicine, as well as bio- and nanotechnology. Their usage ranges from gene delivery through to DNA detection to programmable nano-containers for DNA-templated organic reactions.
合成聚合物与DNA的结合为生物学家、化学家及材料科学家提供了一种极具吸引力的新型杂化材料。通过不同的合成策略克服了制备这些分子嵌合体时遇到的挑战，这些策略依赖于在溶液中或固体载体上偶联核酸部分与有机聚合物。生物有机嵌段共聚物的形态和功能可通过合成聚合物链段的性质以及DNA的序列组成和长度来控制。最近的进展扩大了这些杂化材料在包括生物学和医学以及生物和纳米技术在内的许多不同领域的范围和应用。它们的用途涵盖从基因传递到DNA检测，再到用于DNA模板化有机反应的可编程纳米容器。
