Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Angew Chem Int Ed Engl. 2010 Nov 8;49(46):8574-87. doi: 10.1002/anie.200906820.
Extensive efforts have been devoted to the development of hybrid structures consisting of biomacromolecules and organic polymers connected through covalent bonds. While the combination of proteins and peptides with synthetic macromolecules has been explored in depth, far fewer examples of nucleic acid/polymer hybrids are known. In this Review we give selected examples of this exciting class of materials which can be arranged as linear block copolymer architectures, as side-chain polymers, or as cross-linked networks. Emphasis is placed on the fabrication of these materials as well as on their potential applications in nanoscience, diagnostics, and biomedicine.
人们投入了大量精力来开发通过共价键连接生物大分子和有机聚合物的杂化结构。虽然已经深入研究了将蛋白质和肽与合成大分子结合的方法，但已知的核酸/聚合物杂化的例子要少得多。在这篇综述中，我们给出了这类令人兴奋的材料的一些实例，它们可以被排列成线性嵌段共聚物结构、侧链聚合物或交联网络。重点介绍了这些材料的制备及其在纳米科学、诊断和生物医学中的潜在应用。
