钯催化串联N-芳基化/碳胺化反应立体选择性合成N-芳基-2-苄基吡咯烷
Palladium-catalyzed tandem N-arylation/carboamination reactions for the stereoselective synthesis of N-aryl-2-benzyl pyrrolidines.
作者信息
Yang Qifei, Ney Joshua E, Wolfe John P
机构信息
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.
出版信息
Org Lett. 2005 Jun 23;7(13):2575-8. doi: 10.1021/ol050647u.
Abstract
[reaction: see text] The tandem N-arylation/carboamination of gamma-amino alkenes with two different aryl bromides provides rapid entry to differentially arylated N-aryl-2-benzyl pyrrolidine derivatives in good yields with good to excellent levels of diastereoselectivity. The selective diarylation is achieved in a one-pot process by an in situ modification of the palladium catalyst via phosphine ligand exchange.
摘要
[反应：见正文] γ-氨基烯烃与两种不同芳基溴的串联N-芳基化/碳胺化反应能够快速制备出具有良好非对映选择性的不同芳基化的N-芳基-2-苄基吡咯烷衍生物，产率良好。通过膦配体交换原位修饰钯催化剂，在一锅法中实现了选择性二芳基化。
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