Rébeillé Fabrice, Alban Claude, Bourguignon Jacques, Ravanel Stéphane, Douce Roland
Institut de Recherches en Technologies et Sciences pour le Vivant, UMR5168 CEA/CNRS/INRA/Université Joseph Fourier Grenoble, CEA-Grenoble, 17 rue des Martyrs, Grenoble Cedex 9, 38054, France,
Photosynth Res. 2007 May;92(2):149-62. doi: 10.1007/s11120-007-9167-z. Epub 2007 Apr 27.
This last decade, many efforts were undertaken to understand how coenzymes, including vitamins, are synthesized in plants. Surprisingly, these metabolic pathways were often "quartered" between different compartments of the plant cell. Among these compartments, mitochondria often appear to have a key role, catalyzing one or several steps in these pathways. In the present review we will illustrate these new and important biosynthetic functions found in plant mitochondria by describing the most recent findings about the synthesis of two vitamins (folate and biotin) and one non-vitamin coenzyme (lipoate). The complexity of these metabolic routes raise intriguing questions, such as how the intermediate metabolites and the end-product coenzymes are exchanged between the various cellular territories, or what are the physiological reasons, if any, for such compartmentalization.
在过去十年中，人们付出了诸多努力来了解包括维生素在内的辅酶是如何在植物中合成的。令人惊讶的是，这些代谢途径常常分布在植物细胞的不同区室之间。在这些区室中，线粒体似乎常常发挥关键作用，催化这些途径中的一个或几个步骤。在本综述中，我们将通过描述关于两种维生素（叶酸和生物素）以及一种非维生素辅酶（硫辛酸）合成的最新发现，来说明植物线粒体中发现的这些新的重要生物合成功能。这些代谢途径的复杂性引发了一些有趣的问题，比如中间代谢物和终产物辅酶是如何在不同的细胞区域之间交换的，或者这种区室化是否有任何生理原因。
