Brady K, Casto S, Lydiard R B, Malcolm R, Arana G
Department of Psychiatry, Medical University South Carolina, Charleston 29425.
Am J Drug Alcohol Abuse. 1991;17(4):389-97. doi: 10.3109/00952999109001598.
The relationship between psychoactive drug abuse and psychopathology is complex. There have been few systematic explorations of substance abuse in psychiatric populations since the recent epidemic of cocaine abuse. To update and further explore the relationship between psychiatric illness and substance abuse, 100 consecutively admitted patients to an inpatient psychiatry unit were administered a drug and alcohol use/abuse questionnaire. Sixty-four percent endorsed current or past problems with substance abuse and 29% met DSM-III-R criteria for substance abuse in the 30 days prior to admission. For the major diagnostic categories, there were no significant differences between groups in percentages of patients with substance abuse disorders. There was a trend (p less than or equal to .2) toward an increased number of lifetime psychiatric hospitalizations in the substance-abusing group. Alcohol was the most common drug of choice followed by stimulants, cannabis, and sedative hypnotics. Differences in drug choices between diagnostic categories are discussed. Forty-three percent of urine drug screens obtained were positive, and of those with positive urine drug screens, 42% denied drug use upon admission. Only 40% of patients with current or past substance abuse problems had received treatment for their chemical dependency. In our sample, while substance abuse was very prevalent, it was underreported and undertreated.
精神活性药物滥用与精神病理学之间的关系很复杂。自最近可卡因滥用流行以来,对精神科患者的药物滥用情况鲜有系统的探索。为了更新并进一步探究精神疾病与药物滥用之间的关系,对一家住院精神科病房连续收治的100名患者进行了药物和酒精使用/滥用问卷调查。64%的患者认可当前或过去存在药物滥用问题,29%的患者在入院前30天符合DSM-III-R的药物滥用标准。对于主要诊断类别,药物滥用障碍患者的比例在各群体之间没有显著差异。药物滥用组的终身精神科住院次数有增加的趋势(p小于或等于0.2)。酒精是最常被选择的药物,其次是兴奋剂、大麻和镇静催眠药。文中讨论了不同诊断类别之间药物选择的差异。所进行的尿液药物筛查中有43%呈阳性,在尿液药物筛查呈阳性的患者中,42%在入院时否认使用过药物。目前或过去有药物滥用问题的患者中只有40%接受过化学依赖治疗。在我们的样本中,虽然药物滥用非常普遍,但报告不足且治疗不充分。