Routy J P, Beaulieu R, Monte M, Saint-Louis J, Sauvageau G, Toma E
AIDS Unit, Hôtel-Dieu de Montréal, Quebec, Canada.
Am J Hematol. 1991 Dec;38(4):327-8. doi: 10.1002/ajh.2830380414.
Two homosexual HIV1-positive male patients with thrombotic thrombopenic purpura (TTP) were found to have past history of immune thrombocytopenia (ITP). The first patient had ITP 10 months prior to TTP and was successfully treated by splenectomy. The second patient had ITP 32 months before TTP. No specific treatment was given for his asymptomatic ITP. Association of HIV infection to TTP seems to be frequent. These two types of purpura have different pathogenic mechanisms but share a common altered immune response to antigenic challenge. The occurrence of ITP and TTP in HIV-positive patients may lead to errors in diagnosis and therapy.
两名患有血栓性血小板减少性紫癜（TTP）的同性恋HIV-1阳性男性患者被发现既往有免疫性血小板减少症（ITP）病史。第一名患者在发生TTP前10个月患有ITP，通过脾切除术成功治愈。第二名患者在发生TTP前32个月患有ITP。对于其无症状的ITP未给予特殊治疗。HIV感染与TTP的关联似乎很常见。这两种紫癜有不同的致病机制，但对抗原刺激的免疫反应改变是共同的。HIV阳性患者中ITP和TTP的发生可能导致诊断和治疗错误。
