自身免疫性急性肝衰竭的临床异质性。
Clinical heterogeneity in autoimmune acute liver failure.
作者信息
Chavez-Tapia Norberto C, Martinez-Salgado Julio, Granados Julio, Uribe Misael, Tellez-Avila Felix I
机构信息
Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga #5. Col. Seccion XVI. Del. Tlalpan. CP 14000, Distrito Federal, Mexico.
出版信息
World J Gastroenterol. 2007 Mar 28;13(12):1824-7. doi: 10.3748/wjg.v13.i12.1824.
AIM
To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation.
METHODS
A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed.
RESULTS
Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids.
CONCLUSION
We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids.
目的
描述一组自身免疫性肝炎所致急性肝衰竭且未接受肝移植患者的结局和预后。
方法
对就诊于萨尔瓦多·苏比拉án国立医学与营养科学研究所的11例自身免疫性肝炎所致急性肝衰竭患者进行了一项回顾性试验。评估了人口统计学、生化和严重程度指标以及治疗和结局。
结果
11例患者的中位年龄为31岁，72%发生炎症反应综合征，6例患者接受了皮质类固醇治疗。四周内死亡率为56%，一年生存率为27%。在幸存者中，严重程度指标较低，83%接受了皮质类固醇治疗。
结论
我们观察到自身免疫性肝炎所致急性肝衰竭患者的生存率相对较高。该生存率可能受疾病严重程度和/或皮质类固醇使用的影响。
Zotero 插件