Hawley John A, Spargo Fiona J
Exercise Metabolism Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia.
Sports Med. 2007;37(4-5):328-31. doi: 10.2165/00007256-200737040-00014.
During the past 30 years, considerable progress has been made in our understanding of the cellular and molecular factors regulating fuel metabolism during exercise. In particular, advancements in the fields of exercise biochemistry and cell signalling have helped elucidate the mechanism(s) by which perturbations in energy status are monitored inside contracting muscle cells, and have helped identify target molecules that increase fuel supply to maintain adenosine triphosphate concentration. In this brief commentary, we summarise some of the major cellular and molecular adaptations in human skeletal muscle resulting from the intense endurance training required to run a marathon.
在过去30年里，我们对运动期间调节燃料代谢的细胞和分子因素的理解取得了显著进展。特别是，运动生物化学和细胞信号领域的进展有助于阐明收缩肌肉细胞内能量状态扰动的监测机制，并有助于识别增加燃料供应以维持三磷酸腺苷浓度的靶分子。在这篇简短的评论中，我们总结了马拉松跑步所需的高强度耐力训练导致的人类骨骼肌的一些主要细胞和分子适应性变化。
