Papkoff Jackie
Expert Opin Ther Targets. 2007 May;11(5):585-8. doi: 10.1517/14728222.11.5.585.
Monoclonal antibodies are a rapidly growing class of drugs used for therapy of human cancers and other diseases. They can be used effectively to target tumor-specific molecules and thereby modulate key signaling pathways that play a role in tumor growth, survival and metastasis. Clinical success of novel antibodies has stimulated great interest in the promise of antibody therapeutics for cancer. In this editorial, the author describes three key characteristics that define an ideal target antigen for a therapeutic antibody.
单克隆抗体是一类快速发展的药物，用于治疗人类癌症和其他疾病。它们可以有效地靶向肿瘤特异性分子，从而调节在肿瘤生长、存活和转移中起作用的关键信号通路。新型抗体的临床成功激发了人们对抗体疗法治疗癌症前景的极大兴趣。在这篇社论中，作者描述了定义治疗性抗体理想靶抗原的三个关键特征。
