Lim Chi Young, Yun Ji-Sup, Lee Jandee, Nam Kee-Hyun, Chung Woong Youn, Park Cheong Soo
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Thyroid. 2007 Apr;17(4):347-50. doi: 10.1089/thy.2006.0251.
Percutaneous ethanol injection therapy (PEIT) has been used to treat various human neoplasms. We evaluated the local therapeutic effect of PEIT in recurrent thyroid cancers.
From October 2002 to September 2005, we performed ultrasound-guided PEIT on 24 recurrent lesions (eight in thyroid beds and 16 in neck nodes) of 16 papillary thyroid carcinoma patients. Ethanol was injected at 3-month intervals under sonographic guidance.
All patients tolerated PEIT well with only mild local pain, although one patient complained of transient hoarseness after the procedure. The median diameter of lesions was significantly reduced, from 9.9 mm (range, 5.5-25.0 mm) to 5.3 mm (range, 0.0-17.0 mm) by PEIT. Four recurrent lesions disappeared sonographically.
PEIT may be an alternative treatment option for locally recurrent thyroid carcinomas in properly selected patients. However, a prospective, long-term follow-up study is necessary to determine the effect of PEIT on patient survival and tumor recurrence.
经皮乙醇注射疗法（PEIT）已用于治疗多种人类肿瘤。我们评估了PEIT对复发性甲状腺癌的局部治疗效果。
2002年10月至2005年9月，我们对16例乳头状甲状腺癌患者的24个复发病灶（8个位于甲状腺床，16个位于颈部淋巴结）进行了超声引导下的PEIT。在超声引导下每隔3个月注射一次乙醇。
所有患者对PEIT耐受性良好，仅伴有轻微局部疼痛，尽管有1例患者术后抱怨短暂性声音嘶哑。经PEIT治疗后，病灶的中位直径从9.9毫米（范围5.5 - 25.0毫米）显著缩小至5.3毫米（范围0.0 - 17.0毫米）。4个复发病灶在超声检查中消失。
对于经过适当选择的患者，PEIT可能是局部复发性甲状腺癌的一种替代治疗选择。然而，需要进行前瞻性长期随访研究以确定PEIT对患者生存和肿瘤复发的影响。
